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3OXV

Crystal Structure of HIV-1 I50V, A71 Protease in Complex with the protease inhibitor amprenavir.

3OXV の概要
エントリーDOI10.2210/pdb3oxv/pdb
関連するPDBエントリー3OXW 3OXX 3OY4
分子名称HIV-1 Protease, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, PHOSPHATE ION, ... (7 entities in total)
機能のキーワードhiv-1 protease, inhibitor resistance, aids, aspartyl protease, drug resistance, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種HIV-1 M:B_ARV2/SF2 (HIV-1)
細胞内の位置Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
タンパク質・核酸の鎖数4
化学式量合計45424.43
構造登録者
Schiffer, C.A.,Mittal, S.,Bandaranayake, R.M. (登録日: 2010-09-22, 公開日: 2011-09-28, 最終更新日: 2023-09-06)
主引用文献Mittal, S.,Bandaranayake, R.M.,King, N.M.,Prabu-Jeyabalan, M.,Nalam, M.N.,Nalivaika, E.A.,Yilmaz, N.K.,Schiffer, C.A.
Structural and thermodynamic basis of amprenavir/darunavir and atazanavir resistance in HIV-1 protease with mutations at residue 50.
J.Virol., 87:4176-4184, 2013
Cited by
PubMed: 23365446
DOI: 10.1128/JVI.03486-12
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.75 Å)
構造検証レポート
Validation report summary of 3oxv
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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