3O28

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

3O28 の概要

• エントリーDOI: 10.2210/pdb3o28/pdb
• 関連するPDBエントリー: 3O29 3O2A 3O6G 3O6H 3O6I 3PMV 3PMW 3PMX
• 分子名称: Glutamate receptor 2, 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, GLUTAMIC ACID, ... (7 entities in total)
• 機能のキーワード: transport protein, membrane protein, fusion protein, chimera protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30686.14

構造登録者

Maclean, J.K.F.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Jamieson, C.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L. (登録日: 2010-07-22, 公開日: 2010-09-15, 最終更新日: 2017-08-09)

• 主引用文献: Jamieson, C.,Basten, S.,Campbell, R.A.,Cumming, I.A.,Gillen, K.J.,Gillespie, J.,Kazemier, B.,Kiczun, M.,Lamont, Y.,Lyons, A.J.,Maclean, J.K.,Moir, E.M.,Morrow, J.A.,Papakosta, M.,Rankovic, Z.,Smith, L.; A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies.; Bioorg.Med.Chem.Lett., 20:5753-5756, 2010; PubMed: 20805031; DOI: 10.1016/j.bmcl.2010.07.138

実験手法

X-RAY DIFFRACTION (2 Å)