3O28

Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE O28 A 264

Chain	Residue
A	ILE92
A	GLY219
A	GLY219
A	LEU239
A	SER242
A	LYS104
A	PRO105
A	PRO105
A	SER108
A	SER108
A	SER217
A	LYS218
A	LYS218

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 265

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	LEU138
A	GLY141
A	SER142
A	THR143
A	GLU193
A	HOH278
A	HOH284
A	HOH300

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 266

Chain	Residue
A	GLU24
A	ARG31
A	HIS46
A	LYS240
A	GLN244
A	SO4268
A	HOH319

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 267

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH341
A	HOH373

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 268

Chain	Residue
A	HIS23
A	GLU24
A	ARG31
A	LYS240
A	SO4266

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 269

Chain	Residue
A	GLU27
A	ASN29
A	GLU30
A	ARG149
A	LYS151
A	HOH412

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 270

Chain	Residue
A	GLY62
A	ALA63
A	TRP71
A	THR93
A	VAL95
A	ARG96
A	GLU145
A	HOH312
A	HOH330
A	HOH373

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 271

Chain	Residue
A	GLU97
A	ASP101
A	PHE102
A	LYS104

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 272

Chain	Residue
A	TRP159
A	ARG163

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 273

Chain	Residue
A	GLU27
A	ARG149
A	LYS151
A	GLU243
A	GLN244
A	HOH310
A	HOH367
A	HOH417

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 274

Chain	Residue
A	SER194
A	GLU198
A	ASN214
A	HOH344

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 275

Chain	Residue
A	ASN214
A	ASP216
A	SER217
A	ASP248

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---