3M0C

The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor

3M0C の概要

• エントリーDOI: 10.2210/pdb3m0c/pdb
• 関連するPDBエントリー: 1IJQ 1N7D 2QTW 3GCX
• 分子名称: Proprotein convertase subtilisin/kexin type 9, Low-density lipoprotein receptor, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: protein complex, beta propeller, cholesterol clearance, pcsk9, ldlr, autocatalytic cleavage, cholesterol metabolism, disease mutation, disulfide bond, glycoprotein, hydrolase, lipid metabolism, phosphoprotein, protease, secreted, serine protease, steroid metabolism, zymogen, coated pit, egf-like domain, endocytosis, host-virus interaction, ldl, lipid transport, membrane, receptor, transmembrane, transport, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: Q8NBP7 Q8NBP7; Cell membrane; Single-pass type I membrane protein: P01130
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 160154.66

構造登録者

Spraggon, G.,Hampton, E.N. (登録日: 2010-03-02, 公開日: 2011-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Li, J.,Gavigan, J.A.,Zheng, G.,Huang, W.,Yowe, D.,Geisse, S.,Harris, J.L.,Lesley, S.A.,Spraggon, G.; The X-ray Crystal Structure of PCSK9 in Complex with the LDL receptor; To be Published,

実験手法

X-RAY DIFFRACTION (7.01 Å)