3LTG

Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant

3LTG の概要

• エントリーDOI: 10.2210/pdb3ltg/pdb
• 関連するPDBエントリー: 3CA7 3I2T 3LTF
• 分子名称: Epidermal growth factor receptor, Protein spitz (2 entities in total)
• 機能のキーワード: receptor-ligand complex ectodomain cysteine rich domain egf domain, atp-binding, kinase, nucleotide-binding, receptor, transferase, tyrosine-protein kinase, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, endoplasmic reticulum, glycoprotein, golgi apparatus, membrane, neurogenesis, transmembrane, transferase-transferase regulator complex, transferase/transferase regulator
• 由来する生物種: Drosophila melanogaster; 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P04412; Cell membrane; Single-pass type I membrane protein: Q01083
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 141954.69

構造登録者

Alvarado, D.,Klein, D.E.,Lemmon, M.A. (登録日: 2010-02-15, 公開日: 2010-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Alvarado, D.,Klein, D.E.,Lemmon, M.A.; Structural basis for negative cooperativity in growth factor binding to an EGF receptor.; Cell(Cambridge,Mass.), 142:568-579, 2010; PubMed: 20723758; DOI: 10.1016/j.cell.2010.07.015

実験手法

X-RAY DIFFRACTION (3.4 Å)