3LTF
Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz
Summary for 3LTF
Entry DOI | 10.2210/pdb3ltf/pdb |
Related | 3I2T 3LTG |
Descriptor | Epidermal growth factor receptor, Protein spitz, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | receptor-ligand complex ectodomain cysteine rich domain egf domain, atp-binding, kinase, nucleotide-binding, receptor, transferase, tyrosine-protein kinase, cell membrane, developmental protein, differentiation, disulfide bond, egf-like domain, endoplasmic reticulum, glycoprotein, golgi apparatus, membrane, neurogenesis, transmembrane, transferase-transferase regulator complex, transferase/transferase regulator |
Biological source | Drosophila melanogaster (Fruit fly) More |
Total number of polymer chains | 4 |
Total formula weight | 152414.94 |
Authors | Alvarado, D.,Klein, D.E.,Lemmon, M.A. (deposition date: 2010-02-15, release date: 2010-08-25, Last modification date: 2023-09-06) |
Primary citation | Alvarado, D.,Klein, D.E.,Lemmon, M.A. Structural basis for negative cooperativity in growth factor binding to an EGF receptor. Cell(Cambridge,Mass.), 142:568-579, 2010 Cited by PubMed: 20723758DOI: 10.1016/j.cell.2010.07.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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