3LTF
Crystal Structure of the Drosophila Epidermal Growth Factor Receptor ectodomain in complex with Spitz
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Epidermal growth factor receptor | polymer | 601 | 67970.9 | 2 | UniProt (P04412) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) | Drosophila melanogaster (Fruit fly) | Gurken receptor, Protein torpedo, Drosophila relative of ERBB |
| 2 | C, D (D, B) | Protein spitz | polymer | 58 | 6730.7 | 2 | UniProt (Q01083) | Drosophila melanogaster (Fruit fly) | |
| 3 | E (E) | alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G10025ZX) | |||
| 4 | F (F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G (G) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G48068RF) | |||
| 6 | H, J, K (A, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | I (A) | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) |
Sequence modifications
A, C: 1 - 589 (UniProt: P04412)
| PDB | External Database | Details |
|---|---|---|
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| Glu 38 | Lys 137 | conflict |
| Gly 230 | Ala 329 | conflict |
| Cys 232 | Ser 331 | conflict |
| Leu 359 | Arg 458 | conflict |
| Asn 493 | Thr 592 | conflict |
| His 590 | - | expression tag |
| His 591 | - | expression tag |
| His 592 | - | expression tag |
| His 593 | - | expression tag |
| His 594 | - | expression tag |
| His 595 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149403.2 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2246.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 765.7 | |
| All* | Total formula weight | 152414.9 |
