3LJZ

Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound

Summary for 3LJZ

Entry DOI	10.2210/pdb3ljz/pdb
Related	3HY9 3HYG 3LJT
Descriptor	Collagenase 3, CALCIUM ION, ZINC ION, ... (7 entities in total)
Functional Keywords	mmp-13 inhibitor; zinc chelating agent; s1' pocket, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	4
Total formula weight	78234.15
Authors	Shieh, H.-S.,Kiefer, J.R. (deposition date: 2010-01-26, release date: 2011-02-02, Last modification date: 2024-02-21)
Primary citation	Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D. Structure analysis reveals the flexibility of the ADAMTS-5 active site. Protein Sci., 20:735-744, 2011 Cited by PubMed: 21370305 DOI: 10.1002/pro.606 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation