Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

Summary for 3LJT

Related3HY9 3HYG 3LJZ
DescriptorA disintegrin and metalloproteinase with thrombospondin motifs 5, (2R)-2-[4-(1,3-benzodioxol-5-yl)benzyl]-N~4~-hydroxy-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsalpha/beta structure, central five stranded beta-sheet, cleavage on pair of basic residues, disulfide bond, extracellular matrix, glycoprotein, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix  Q9UNA0
Total number of polymer chains1
Total molecular weight24827.43
Shieh, H.-S.,Williams, J.M.,Caspers, N. (deposition date: 2010-01-26, release date: 2010-03-31, Last modification date: 2017-11-01)
Primary citation
Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D.
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Protein Sci., 20:735-744, 2011
PubMed: 21370305 (PDB entries with the same primary citation)
DOI: 10.1002/pro.606
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20560.5%1.6%7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report