3LJT
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | A disintegrin and metalloproteinase with thrombospondin motifs 5 | polymer | 218 | 24105.2 | 1 | UniProt (Q9UNA0) Pfam (PF01421) | Homo sapiens (human) | ADAMTS-5, ADAM-TS 5, ADAM-TS5, Aggrecanase-2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADAM-TS 11 |
| 2 | B (A) | (2R)-2-[4-(1,3-benzodioxol-5-yl)benzyl]-N~4~-hydroxy-N~1~-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide | non-polymer | 474.5 | 1 | Chemie (LA3) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, G (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | H (A) | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A: 264 - 480 (UniProt: Q9UNA0)
| PDB | External Database | Details |
|---|---|---|
| Ala 263 | - | expression tag |
| Lys 282 | Leu 282 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24105.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 722.2 | |
| All* | Total formula weight | 24827.4 |
