3LJT
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE LA3 A 801 |
| Chain | Residue |
| A | ASP377 |
| A | HIS420 |
| A | LEU438 |
| A | SER440 |
| A | SER441 |
| A | LEU443 |
| A | ILE446 |
| A | ZN901 |
| A | HOH5040 |
| A | HOH5296 |
| A | THR378 |
| A | LEU379 |
| A | GLY380 |
| A | PHE406 |
| A | THR407 |
| A | HIS410 |
| A | GLU411 |
| A | HIS414 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 802 |
| Chain | Residue |
| A | GLY372 |
| A | GLY385 |
| A | THR386 |
| A | SER389 |
| A | HIS468 |
| A | HOH5006 |
| A | HOH5217 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 901 |
| Chain | Residue |
| A | HIS410 |
| A | HIS414 |
| A | HIS420 |
| A | LA3801 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 902 |
| Chain | Residue |
| A | GLU270 |
| A | ASP360 |
| A | CYS471 |
| A | ASP474 |
| A | HOH5009 |
| A | HOH5031 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 903 |
| Chain | Residue |
| A | GLU270 |
| A | ASP474 |
| A | LEU475 |
| A | HOH5068 |
| A | HOH5103 |
| A | HOH5157 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 904 |
| Chain | Residue |
| A | ASP369 |
| A | LEU370 |
| A | CYS376 |
| A | THR378 |
| A | GLU398 |
| A | HOH5014 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL |
| Chain | Residue | Details |
| A | THR407-LEU416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 209 |
| Details | Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
