3LJT

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LA3 A 801

Chain	Residue
A	ASP377
A	HIS420
A	LEU438
A	SER440
A	SER441
A	LEU443
A	ILE446
A	ZN901
A	HOH5040
A	HOH5296
A	THR378
A	LEU379
A	GLY380
A	PHE406
A	THR407
A	HIS410
A	GLU411
A	HIS414

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 802

Chain	Residue
A	GLY372
A	GLY385
A	THR386
A	SER389
A	HIS468
A	HOH5006
A	HOH5217

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 901

Chain	Residue
A	HIS410
A	HIS414
A	HIS420
A	LA3801

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 902

Chain	Residue
A	GLU270
A	ASP360
A	CYS471
A	ASP474
A	HOH5009
A	HOH5031

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 903

Chain	Residue
A	GLU270
A	ASP474
A	LEU475
A	HOH5068
A	HOH5103
A	HOH5157

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 904

Chain	Residue
A	ASP369
A	LEU370
A	CYS376
A	THR378
A	GLU398
A	HOH5014

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL

Chain	Residue	Details
A	THR407-LEU416

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:18042673

Chain	Residue	Details
A	GLU411

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18042673

Chain	Residue	Details
A	HIS410
A	HIS414
A	HIS420

---