3LJZ

Crystal Structure of Human MMP-13 complexed with an Amino-2-indanol compound

Summary for 3LJZ

Related3HY9 3HYG 3LJT
DescriptorCollagenase 3, CALCIUM ION, ZINC ION, ... (7 entities in total)
Functional Keywordsmmp-13 inhibitor; zinc chelating agent; s1' pocket, collagen degradation, disease mutation, disulfide bond, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted, extracellular space, extracellular matrix  P45452
Total number of polymer chains4
Total molecular weight78234.15
Authors
Shieh, H.-S.,Kiefer, J.R. (deposition date: 2010-01-26, release date: 2011-02-02, Last modification date: 2017-11-01)
Primary citation
Shieh, H.S.,Tomasselli, A.G.,Mathis, K.J.,Schnute, M.E.,Woodard, S.S.,Caspers, N.,Williams, J.M.,Kiefer, J.R.,Munie, G.,Wittwer, A.,Malfait, A.M.,Tortorella, M.D.
Structure analysis reveals the flexibility of the ADAMTS-5 active site.
Protein Sci., 20:735-744, 2011
PubMed: 21370305 (PDB entries with the same primary citation)
DOI: 10.1002/pro.606
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24220.6%2.9%9.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution