Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
D | 0004222 | molecular_function | metalloendopeptidase activity |
D | 0006508 | biological_process | proteolysis |
D | 0008237 | molecular_function | metallopeptidase activity |
D | 0008270 | molecular_function | zinc ion binding |
D | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE CA A 996 |
Chain | Residue |
A | ALA161 |
A | ASP162 |
A | ASN194 |
A | GLY196 |
A | ASP198 |
A | HOH280 |
A | HOH340 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 997 |
Chain | Residue |
A | SER182 |
A | LEU184 |
A | ASP202 |
A | GLU205 |
A | ASP179 |
A | GLY180 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 998 |
Chain | Residue |
A | HIS172 |
A | ASP174 |
A | HIS187 |
A | HIS200 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 999 |
Chain | Residue |
A | HIS222 |
A | HIS226 |
A | HIS232 |
A | LA3801 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 1 |
Chain | Residue |
A | HOH43 |
A | TYR120 |
A | LYS139 |
A | ARG155 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 5 |
Chain | Residue |
A | LYS115 |
A | MET116 |
A | ASN117 |
site_id | AC7 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE LA3 A 801 |
Chain | Residue |
A | LEU184 |
A | LEU185 |
A | ALA186 |
A | LEU218 |
A | HIS222 |
A | GLU223 |
A | HIS226 |
A | HIS232 |
A | LEU239 |
A | PHE241 |
A | PRO242 |
A | ILE243 |
A | TYR244 |
A | THR245 |
A | HOH291 |
A | HOH292 |
A | ZN999 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 996 |
Chain | Residue |
B | ALA161 |
B | ASP162 |
B | ASN194 |
B | GLY196 |
B | ASP198 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 997 |
Chain | Residue |
B | ASP179 |
B | GLY180 |
B | SER182 |
B | LEU184 |
B | ASP202 |
B | GLU205 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 998 |
Chain | Residue |
B | HIS172 |
B | ASP174 |
B | HIS187 |
B | HIS200 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 999 |
Chain | Residue |
B | HIS222 |
B | HIS226 |
B | HIS232 |
B | LA3802 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EPE B 3 |
Chain | Residue |
B | HOH4 |
B | HOH87 |
B | TYR176 |
B | PRO190 |
B | ASP231 |
B | HIS232 |
B | HOH277 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 2 |
Chain | Residue |
B | HOH77 |
B | HOH92 |
B | LYS139 |
B | ARG155 |
B | HOH298 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 6 |
Chain | Residue |
A | PRO236 |
B | LYS115 |
B | MET116 |
B | ASN117 |
B | HOH307 |
B | HOH312 |
site_id | BC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE LA3 B 802 |
Chain | Residue |
B | THR245 |
B | THR247 |
B | ZN999 |
A | HOH98 |
B | HOH4 |
B | GLY183 |
B | LEU184 |
B | LEU185 |
B | ALA186 |
B | LEU218 |
B | HIS222 |
B | GLU223 |
B | HIS226 |
B | HIS232 |
B | ALA238 |
B | LEU239 |
B | PHE241 |
B | PRO242 |
B | ILE243 |
B | TYR244 |
site_id | BC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA C 996 |
Chain | Residue |
C | ALA161 |
C | ASP162 |
C | ASN194 |
C | GLY196 |
C | ASP198 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 997 |
Chain | Residue |
C | ASP179 |
C | GLY180 |
C | SER182 |
C | LEU184 |
C | ASP202 |
C | GLU205 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 998 |
Chain | Residue |
C | HIS172 |
C | ASP174 |
C | HIS187 |
C | HIS200 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 999 |
Chain | Residue |
C | HIS222 |
C | HIS226 |
C | HIS232 |
C | LA3803 |
site_id | CC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EPE C 1 |
Chain | Residue |
C | TYR176 |
C | LEU184 |
C | HIS187 |
C | ALA188 |
C | PHE189 |
C | PRO190 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 C 3 |
Chain | Residue |
C | HOH45 |
C | TYR120 |
C | LYS139 |
C | ARG155 |
C | HOH311 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 7 |
Chain | Residue |
C | LYS115 |
C | MET116 |
C | ASN117 |
site_id | CC5 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE LA3 C 803 |
Chain | Residue |
C | HOH10 |
C | LEU184 |
C | LEU185 |
C | ALA186 |
C | LEU218 |
C | HIS222 |
C | GLU223 |
C | HIS226 |
C | HIS232 |
C | ALA238 |
C | LEU239 |
C | PHE241 |
C | PRO242 |
C | ILE243 |
C | TYR244 |
C | THR245 |
C | ZN999 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA D 996 |
Chain | Residue |
D | HOH57 |
D | ASP162 |
D | ASN194 |
D | GLY196 |
D | ASP198 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA D 997 |
Chain | Residue |
D | ASP179 |
D | GLY180 |
D | SER182 |
D | LEU184 |
D | ASP202 |
D | GLU205 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 998 |
Chain | Residue |
D | HIS172 |
D | ASP174 |
D | HIS187 |
D | HIS200 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 999 |
Chain | Residue |
D | HIS222 |
D | HIS226 |
D | HIS232 |
D | LA3804 |
site_id | DC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EPE D 2 |
Chain | Residue |
B | PRO193 |
B | ASN194 |
D | TYR176 |
D | LEU184 |
D | HIS187 |
D | PHE189 |
D | PRO190 |
D | HOH289 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EPE D 4 |
Chain | Residue |
D | GLU133 |
D | ALA137 |
D | LYS140 |
D | SER209 |
D | PHE217 |
D | HOH271 |
D | HOH350 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 268 |
Chain | Residue |
D | HOH7 |
D | LYS139 |
D | ARG155 |
D | HOH321 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 8 |
Chain | Residue |
D | LYS115 |
D | MET116 |
D | ASN117 |
site_id | DC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 D 9 |
Chain | Residue |
D | PRO108 |
D | ARG109 |
site_id | DC6 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE LA3 D 804 |
Chain | Residue |
D | HOH26 |
D | GLY183 |
D | LEU184 |
D | LEU185 |
D | ALA186 |
D | LEU218 |
D | HIS222 |
D | GLU223 |
D | HIS226 |
D | HIS232 |
D | ALA238 |
D | LEU239 |
D | PHE241 |
D | PRO242 |
D | ILE243 |
D | TYR244 |
D | THR245 |
D | HOH307 |
D | HOH312 |
D | ZN999 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
Chain | Residue | Details |
A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU223 | |
B | GLU223 | |
C | GLU223 | |
D | GLU223 | |
site_id | SWS_FT_FI2 |
Number of Residues | 48 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
Chain | Residue | Details |
A | ASP128 | |
A | ASP202 | |
A | ASP203 | |
A | GLU205 | |
B | ASP128 | |
B | ASP162 | |
B | ASP179 | |
B | GLY180 | |
B | SER182 | |
B | LEU184 | |
B | ASN194 | |
A | ASP162 | |
B | GLY196 | |
B | ASP198 | |
B | ASP202 | |
B | ASP203 | |
B | GLU205 | |
C | ASP128 | |
C | ASP162 | |
C | ASP179 | |
C | GLY180 | |
C | SER182 | |
A | ASP179 | |
C | LEU184 | |
C | ASN194 | |
C | GLY196 | |
C | ASP198 | |
C | ASP202 | |
C | ASP203 | |
C | GLU205 | |
D | ASP128 | |
D | ASP162 | |
D | ASP179 | |
A | GLY180 | |
D | GLY180 | |
D | SER182 | |
D | LEU184 | |
D | ASN194 | |
D | GLY196 | |
D | ASP198 | |
D | ASP202 | |
D | ASP203 | |
D | GLU205 | |
A | SER182 | |
A | LEU184 | |
A | ASN194 | |
A | GLY196 | |
A | ASP198 | |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
Chain | Residue | Details |
A | HIS172 | |
B | ASP174 | |
B | HIS187 | |
B | HIS200 | |
B | HIS222 | |
B | HIS226 | |
B | HIS232 | |
B | MET240 | |
C | HIS172 | |
C | ASP174 | |
C | HIS187 | |
A | ASP174 | |
C | HIS200 | |
C | HIS222 | |
C | HIS226 | |
C | HIS232 | |
C | MET240 | |
D | HIS172 | |
D | ASP174 | |
D | HIS187 | |
D | HIS200 | |
D | HIS222 | |
A | HIS187 | |
D | HIS226 | |
D | HIS232 | |
D | MET240 | |
A | HIS200 | |
A | HIS222 | |
A | HIS226 | |
A | HIS232 | |
A | MET240 | |
B | HIS172 | |
Chain | Residue | Details |
A | ASN117 | |
B | ASN117 | |
C | ASN117 | |
D | ASN117 | |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN152 | |
B | ASN152 | |
C | ASN152 | |
D | ASN152 | |