3KRD

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B

Summary for 3KRD

• Entry DOI: 10.2210/pdb3krd/pdb
• Related: 2FHG 2FHH 3H6F 3H6I 3HF9 3HFA
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, Fellutamide B, ... (5 entities in total)
• Functional Keywords: binding sites, mycobacterium tuberculosis, protein subunits, substrate specificity, hydrolase, proteasome, fellutamide b, inhibition, protease, threonine protease, virulence, autocatalytic cleavage, zymogen
• Biological source: Mycobacterium tuberculosis; More
• Cellular location: Cytoplasm (By similarity): A5U4D5 A5U4D6
• Total number of polymer chains: 42
• Total formula weight: 738850.35

Authors

Li, D.,Li, H. (deposition date: 2009-11-18, release date: 2010-09-29, Last modification date: 2024-03-27)

• Primary citation: Lin, G.,Li, D.,Chidawanyika, T.,Nathan, C.,Li, H.; Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.; Arch.Biochem.Biophys., 501:214-220, 2010; PubMed: 20558127; DOI: 10.1016/j.abb.2010.06.009

Experimental method

X-RAY DIFFRACTION (2.5 Å)