2FHH
Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with a peptidyl boronate inhibitor MLN-273
Summary for 2FHH
Entry DOI | 10.2210/pdb2fhh/pdb |
Related | 2FHG |
Descriptor | 20S proteasome, alpha and beta subunits, proteasome, beta subunit, (1R)-3-METHYL-1-{[N-(MORPHOLIN-4-YLCARBONYL)-3-(1-NAPHTHYL)-D-ALANYL]AMINO}BUTYLBORONIC ACID, ... (4 entities in total) |
Functional Keywords | multi-subunit protein assembly, inhibitor-complex, hydrolase |
Biological source | Mycobacterium tuberculosis More |
Total number of polymer chains | 28 |
Total formula weight | 740808.45 |
Authors | |
Primary citation | Hu, G.,Lin, G.,Wang, M.,Dick, L.,Xu, R.M.,Nathan, C.,Li, H. Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate. Mol.Microbiol., 59:1417-1428, 2006 Cited by PubMed: 16468986DOI: 10.1111/j.1365-2958.2005.05036.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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