3KRD

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, AA, B, D, F... (A, B, D, F, I...)	Proteasome subunit alpha	polymer	248	26911.0	14	UniProt (A5U4D5) Pfam (PF00227) UniProt (by SIFTS) (P9WHU1)	Mycobacterium tuberculosis	20S proteasome alpha subunit,Proteasome core protein PrcA
2	BA, C, E, G, H... (C, E, G, H, J...)	Proteasome subunit beta	polymer	240	25274.3	14	UniProt (A5U4D6) Pfam (PF00227) UniProt (by SIFTS) (P9WHT9)	Mycobacterium tuberculosis	20S proteasome beta subunit,Proteasome core protein PrcB
3	CA, DA, EA, FA, GA... (a, b, c, d, e...)	Fellutamide B	polymer	3	373.4	14		synthetic construct
4	AB, BB, CB, DB, QA... (k, l, m, n, a...)	(3R)-3-HYDROXYDODECANOIC ACID	non-polymer		216.3	14	Chemie (HXD)
5	AC, BC, CC, DC, EB... (W, X, Y, Z, A...)	water	water		18.0	2225	Chemie (HOH)

Sequence modifications

C, E, G, H, J, L, N, P, R, T, V, X, Z, 2: 301 - 534 (UniProt: A5U4D6)

PDB	External Database	Details
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag
His 540	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	42
	Total formula weight	735821.9
Non-Polymers*	Number of molecules	14
	Total formula weight	3028.4
All*	Total formula weight	738850.4

*Water molecules are not included.