3KQ6

Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog

Summary for 3KQ6

• Entry DOI: 10.2210/pdb3kq6/pdb
• Related: 1RWE
• Descriptor: Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
• Functional Keywords: zinc-binding site, long-acting insulin analog, receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 12088.70

Authors

Wan, Z.L.,Hu, S.Q.,Whittaker, L.,Phillips, N.B.,Whittake, J.,Ismail-Beigi, F.,Weiss, M.A. (deposition date: 2009-11-17, release date: 2010-02-23, Last modification date: 2023-09-06)

• Primary citation: Phillips, N.B.,Wan, Z.L.,Whittaker, L.,Hu, S.Q.,Huang, K.,Hua, Q.X.,Whittaker, J.,Ismail-Beigi, F.,Weiss, M.A.; Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.; J.Biol.Chem., 285:11755-11759, 2010; PubMed: 20181952; DOI: 10.1074/jbc.C110.105825

Experimental method

X-RAY DIFFRACTION (1.9 Å)