3KQ6

Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog

3KQ6 の概要

• エントリーDOI: 10.2210/pdb3kq6/pdb
• 関連するPDBエントリー: 1RWE
• 分子名称: Insulin A chain, Insulin B chain, ZINC ION, ... (6 entities in total)
• 機能のキーワード: zinc-binding site, long-acting insulin analog, receptor binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, pharmaceutical, secreted
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P01308 P01308
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 12088.70

構造登録者

Wan, Z.L.,Hu, S.Q.,Whittaker, L.,Phillips, N.B.,Whittake, J.,Ismail-Beigi, F.,Weiss, M.A. (登録日: 2009-11-17, 公開日: 2010-02-23, 最終更新日: 2023-09-06)

• 主引用文献: Phillips, N.B.,Wan, Z.L.,Whittaker, L.,Hu, S.Q.,Huang, K.,Hua, Q.X.,Whittaker, J.,Ismail-Beigi, F.,Weiss, M.A.; Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.; J.Biol.Chem., 285:11755-11759, 2010; PubMed: 20181952; DOI: 10.1074/jbc.C110.105825

実験手法

X-RAY DIFFRACTION (1.9 Å)