3KHU
Crystal structure of human UDP-glucose dehydrogenase Glu161Gln, in complex with thiohemiacetal intermediate
Summary for 3KHU
Entry DOI | 10.2210/pdb3khu/pdb |
Related | 2Q3E 2QG4 3ITK |
Descriptor | UDP-glucose 6-dehydrogenase, URIDINE-5'-DIPHOSPHATE-GLUCOSE, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | oxidoreductase, thiohemiacetal intermediate, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 6 |
Total formula weight | 320583.69 |
Authors | Chaikuad, A.,Egger, S.,Yue, W.W.,Guo, K.,Sethi, R.,Filippakopoulos, P.,Muniz, J.R.C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,Kavanagh, K.L.,Nidetzky, B.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2009-10-30, release date: 2009-11-17, Last modification date: 2023-09-06) |
Primary citation | Egger, S.,Chaikuad, A.,Klimacek, M.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B. Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates. J.Biol.Chem., 287:2119-2129, 2012 Cited by PubMed: 22123821DOI: 10.1074/jbc.M111.313015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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