2Q3E

Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose

Summary for 2Q3E

• Entry DOI: 10.2210/pdb2q3e/pdb
• Descriptor: UDP-glucose 6-dehydrogenase, CHLORIDE ION, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: udp-glucose 6-dehydrogenase, hexamer, structural genomics, structural genomics consortium, sgc, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 640207.37

Authors

Kavanagh, K.L.,Guo, K.,Bunkoczi, G.,Savitsky, P.,Pilka, E.,Bhatia, C.,Smee, C.,Berridge, G.,von Delft, F.,Wiegelt, J.,Arrowsmith, C.,Sundstrom, M.,Edwards, A.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2007-05-30, release date: 2007-07-03, Last modification date: 2023-08-30)

• Primary citation: Egger, S.,Chaikuad, A.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B.; Structure and mechanism of human UDP-glucose 6-dehydrogenase.; J.Biol.Chem., 286:23877-23887, 2011; PubMed: 21502315; DOI: 10.1074/jbc.M111.234682

Experimental method

X-RAY DIFFRACTION (2 Å)