3KHU
Crystal structure of human UDP-glucose dehydrogenase Glu161Gln, in complex with thiohemiacetal intermediate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001702 | biological_process | gastrulation with mouth forming second |
| A | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| A | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| A | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| A | 0034214 | biological_process | protein hexamerization |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0048666 | biological_process | neuron development |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001702 | biological_process | gastrulation with mouth forming second |
| B | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| B | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| B | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| B | 0034214 | biological_process | protein hexamerization |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0048666 | biological_process | neuron development |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0001702 | biological_process | gastrulation with mouth forming second |
| C | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| C | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| C | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| C | 0034214 | biological_process | protein hexamerization |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0048666 | biological_process | neuron development |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0001702 | biological_process | gastrulation with mouth forming second |
| D | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| D | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| D | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| D | 0034214 | biological_process | protein hexamerization |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0048666 | biological_process | neuron development |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070062 | cellular_component | extracellular exosome |
| E | 0001702 | biological_process | gastrulation with mouth forming second |
| E | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| E | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| E | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| E | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| E | 0034214 | biological_process | protein hexamerization |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0048666 | biological_process | neuron development |
| E | 0051287 | molecular_function | NAD binding |
| E | 0070062 | cellular_component | extracellular exosome |
| F | 0001702 | biological_process | gastrulation with mouth forming second |
| F | 0003979 | molecular_function | UDP-glucose 6-dehydrogenase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006024 | biological_process | glycosaminoglycan biosynthetic process |
| F | 0006065 | biological_process | UDP-glucuronate biosynthetic process |
| F | 0015012 | biological_process | heparan sulfate proteoglycan biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| F | 0030206 | biological_process | chondroitin sulfate biosynthetic process |
| F | 0034214 | biological_process | protein hexamerization |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0048666 | biological_process | neuron development |
| F | 0051287 | molecular_function | NAD binding |
| F | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE UPG A 501 |
| Chain | Residue |
| A | GLN161 |
| A | LEU266 |
| A | LYS267 |
| A | SER269 |
| A | PHE272 |
| A | GLY273 |
| A | CYS276 |
| A | PHE277 |
| A | PHE338 |
| A | LYS339 |
| A | ARG442 |
| A | PHE162 |
| A | HOH485 |
| A | HOH521 |
| A | HOH530 |
| A | HOH543 |
| A | HOH596 |
| A | EDO615 |
| A | HOH655 |
| A | HOH831 |
| A | HOH951 |
| A | HOH1195 |
| A | LEU163 |
| B | ARG260 |
| A | ALA164 |
| A | GLU165 |
| A | LYS220 |
| A | ASN224 |
| A | ILE231 |
| A | PHE265 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UPG A 502 |
| Chain | Residue |
| A | GLY11 |
| A | GLY13 |
| A | TYR14 |
| A | VAL15 |
| A | ASP36 |
| A | VAL37 |
| A | ARG41 |
| A | SER88 |
| A | VAL89 |
| A | ASN90 |
| A | SER130 |
| A | THR131 |
| A | GLN161 |
| A | SER275 |
| A | CYS276 |
| A | ARG346 |
| A | HOH508 |
| A | HOH517 |
| A | HOH565 |
| A | HOH1193 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 611 |
| Chain | Residue |
| A | PHE2 |
| A | GLU3 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 614 |
| Chain | Residue |
| A | GLU289 |
| A | ALA297 |
| A | ARG298 |
| A | GLN301 |
| A | HOH886 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 615 |
| Chain | Residue |
| A | ALA268 |
| A | SER269 |
| A | ARG442 |
| A | UPG501 |
| A | HOH951 |
| site_id | AC6 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE UPG B 501 |
| Chain | Residue |
| A | ARG260 |
| B | GLN161 |
| B | PHE162 |
| B | LEU163 |
| B | ALA164 |
| B | GLU165 |
| B | LYS220 |
| B | ASN224 |
| B | ILE231 |
| B | PHE265 |
| B | LEU266 |
| B | LYS267 |
| B | SER269 |
| B | PHE272 |
| B | GLY273 |
| B | CYS276 |
| B | PHE277 |
| B | PHE338 |
| B | LYS339 |
| B | ARG442 |
| B | HOH468 |
| B | HOH475 |
| B | HOH504 |
| B | HOH534 |
| B | HOH541 |
| B | EDO608 |
| B | HOH739 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE UPG B 502 |
| Chain | Residue |
| B | SER130 |
| B | THR131 |
| B | GLN161 |
| B | SER275 |
| B | CYS276 |
| B | ARG346 |
| B | HOH1027 |
| B | HOH1163 |
| B | HOH1211 |
| B | GLY11 |
| B | GLY13 |
| B | TYR14 |
| B | VAL15 |
| B | ASP36 |
| B | VAL37 |
| B | ASN38 |
| B | ARG41 |
| B | ASN90 |
| B | TYR108 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 601 |
| Chain | Residue |
| A | GLN229 |
| A | TYR299 |
| A | VAL303 |
| B | GLN229 |
| B | TYR299 |
| B | VAL303 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 602 |
| Chain | Residue |
| B | THR91 |
| B | ALA104 |
| B | LYS279 |
| B | ASP280 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 607 |
| Chain | Residue |
| B | GLU249 |
| B | ALA252 |
| B | ASN263 |
| B | HOH546 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 608 |
| Chain | Residue |
| B | PHE265 |
| B | UPG501 |
| B | HOH541 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 612 |
| Chain | Residue |
| B | LEU423 |
| B | TYR425 |
| B | GLU451 |
| B | HOH564 |
| site_id | BC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE UPG C 501 |
| Chain | Residue |
| C | GLN161 |
| C | PHE162 |
| C | LEU163 |
| C | ALA164 |
| C | GLU165 |
| C | LYS220 |
| C | ASN224 |
| C | ILE231 |
| C | PHE265 |
| C | LEU266 |
| C | LYS267 |
| C | SER269 |
| C | PHE272 |
| C | GLY273 |
| C | CYS276 |
| C | PHE277 |
| C | PHE338 |
| C | LYS339 |
| C | ARG442 |
| C | HOH504 |
| C | HOH506 |
| C | HOH517 |
| C | HOH625 |
| C | HOH825 |
| C | HOH1000 |
| C | HOH1001 |
| C | HOH1123 |
| D | ARG260 |
| site_id | BC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UPG C 502 |
| Chain | Residue |
| C | GLY13 |
| C | TYR14 |
| C | VAL15 |
| C | ASP36 |
| C | VAL37 |
| C | ARG41 |
| C | VAL89 |
| C | ASN90 |
| C | SER130 |
| C | THR131 |
| C | GLN161 |
| C | SER275 |
| C | ARG346 |
| C | HOH484 |
| C | HOH491 |
| C | HOH1008 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 604 |
| Chain | Residue |
| C | ASP328 |
| C | HIS363 |
| C | HIS365 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 609 |
| Chain | Residue |
| C | VAL156 |
| C | ASP183 |
| C | THR213 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO C 616 |
| Chain | Residue |
| C | GLU289 |
| C | ARG298 |
| C | GLN301 |
| C | HOH902 |
| site_id | BC9 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE UPG D 501 |
| Chain | Residue |
| C | ARG260 |
| C | HOH618 |
| D | PHE162 |
| D | LEU163 |
| D | ALA164 |
| D | GLU165 |
| D | LYS220 |
| D | ASN224 |
| D | ILE231 |
| D | PHE265 |
| D | LEU266 |
| D | LYS267 |
| D | SER269 |
| D | PHE272 |
| D | GLY273 |
| D | CYS276 |
| D | PHE277 |
| D | PHE338 |
| D | LYS339 |
| D | ARG442 |
| D | HOH521 |
| D | HOH537 |
| D | HOH610 |
| D | HOH991 |
| D | HOH1022 |
| D | HOH1168 |
| site_id | CC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UPG D 502 |
| Chain | Residue |
| D | GLY11 |
| D | GLY13 |
| D | TYR14 |
| D | VAL15 |
| D | ASP36 |
| D | VAL37 |
| D | ARG41 |
| D | VAL89 |
| D | ASN90 |
| D | TYR108 |
| D | SER130 |
| D | THR131 |
| D | GLN161 |
| D | SER275 |
| D | ARG346 |
| D | HOH513 |
| D | HOH791 |
| D | HOH953 |
| D | HOH1172 |
| D | HOH1183 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE D 618 |
| Chain | Residue |
| C | GLU184 |
| D | GLY447 |
| D | HIS449 |
| D | ASN450 |
| D | LYS464 |
| D | HOH803 |
| site_id | CC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE UPG E 501 |
| Chain | Residue |
| E | PHE162 |
| E | LEU163 |
| E | ALA164 |
| E | GLU165 |
| E | LYS220 |
| E | ASN224 |
| E | ILE231 |
| E | PHE265 |
| E | LEU266 |
| E | LYS267 |
| E | SER269 |
| E | PHE272 |
| E | GLY273 |
| E | CYS276 |
| E | PHE277 |
| E | PHE338 |
| E | LYS339 |
| E | ARG442 |
| E | HOH473 |
| E | HOH486 |
| E | HOH490 |
| E | UPG502 |
| E | HOH526 |
| E | HOH900 |
| E | HOH1005 |
| E | HOH1182 |
| F | ARG260 |
| site_id | CC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UPG E 502 |
| Chain | Residue |
| E | GLY13 |
| E | TYR14 |
| E | VAL15 |
| E | ASP36 |
| E | VAL37 |
| E | ARG41 |
| E | TYR108 |
| E | SER130 |
| E | THR131 |
| E | SER275 |
| E | CYS276 |
| E | ARG346 |
| E | UPG501 |
| E | HOH505 |
| E | HOH518 |
| E | EDO613 |
| E | HOH1176 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO E 603 |
| Chain | Residue |
| E | ILE52 |
| E | TYR53 |
| E | GLU54 |
| E | GLY56 |
| E | LEU57 |
| E | LYS58 |
| E | GLU59 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 605 |
| Chain | Residue |
| E | HIS363 |
| E | HIS365 |
| E | ARG393 |
| E | LEU394 |
| E | HOH891 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 606 |
| Chain | Residue |
| E | LYS421 |
| E | GLU422 |
| E | LEU423 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 610 |
| Chain | Residue |
| E | ALA268 |
| E | SER269 |
| E | ARG442 |
| E | HOH900 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO E 613 |
| Chain | Residue |
| E | VAL37 |
| E | ARG115 |
| E | UPG502 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO E 617 |
| Chain | Residue |
| A | TYR96 |
| E | MET358 |
| E | GLN390 |
| E | ARG393 |
| site_id | DC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE UPG F 501 |
| Chain | Residue |
| E | ARG260 |
| F | GLN161 |
| F | PHE162 |
| F | LEU163 |
| F | GLU165 |
| F | LYS220 |
| F | ASN224 |
| F | ILE231 |
| F | PHE265 |
| F | LEU266 |
| F | LYS267 |
| F | SER269 |
| F | PHE272 |
| F | GLY273 |
| F | CYS276 |
| F | PHE277 |
| F | PHE338 |
| F | LYS339 |
| F | ARG442 |
| F | HOH469 |
| F | HOH480 |
| F | HOH489 |
| F | HOH522 |
| F | HOH760 |
| F | HOH1118 |
| site_id | DC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE UPG F 502 |
| Chain | Residue |
| F | GLY11 |
| F | GLY13 |
| F | TYR14 |
| F | VAL15 |
| F | ASP36 |
| F | VAL37 |
| F | ARG41 |
| F | VAL89 |
| F | SER130 |
| F | THR131 |
| F | GLN161 |
| F | SER275 |
| F | ARG346 |
| F | HOH490 |
| F | HOH498 |
| F | HOH594 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:22123821 |
| Chain | Residue | Details |
| A | GLN161 | |
| E | LYS220 | |
| F | GLN161 | |
| F | LYS220 | |
| A | LYS220 | |
| B | GLN161 | |
| B | LYS220 | |
| C | GLN161 | |
| C | LYS220 | |
| D | GLN161 | |
| D | LYS220 | |
| E | GLN161 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821 |
| Chain | Residue | Details |
| A | CYS276 | |
| B | CYS276 | |
| C | CYS276 | |
| D | CYS276 | |
| E | CYS276 | |
| F | CYS276 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
| Chain | Residue | Details |
| A | GLY11 | |
| B | CYS276 | |
| C | GLY11 | |
| C | ASP36 | |
| C | ARG41 | |
| C | VAL89 | |
| C | CYS276 | |
| D | GLY11 | |
| D | ASP36 | |
| D | ARG41 | |
| D | VAL89 | |
| A | ASP36 | |
| D | CYS276 | |
| E | GLY11 | |
| E | ASP36 | |
| E | ARG41 | |
| E | VAL89 | |
| E | CYS276 | |
| F | GLY11 | |
| F | ASP36 | |
| F | ARG41 | |
| F | VAL89 | |
| A | ARG41 | |
| F | CYS276 | |
| A | VAL89 | |
| A | CYS276 | |
| B | GLY11 | |
| B | ASP36 | |
| B | ARG41 | |
| B | VAL89 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445 |
| Chain | Residue | Details |
| A | SER130 | |
| B | SER130 | |
| C | SER130 | |
| D | SER130 | |
| E | SER130 | |
| F | SER130 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
| Chain | Residue | Details |
| A | GLN161 | |
| C | LYS220 | |
| C | LYS267 | |
| C | PHE338 | |
| D | GLN161 | |
| D | LYS220 | |
| D | LYS267 | |
| D | PHE338 | |
| E | GLN161 | |
| E | LYS220 | |
| E | LYS267 | |
| A | LYS220 | |
| E | PHE338 | |
| F | GLN161 | |
| F | LYS220 | |
| F | LYS267 | |
| F | PHE338 | |
| A | LYS267 | |
| A | PHE338 | |
| B | GLN161 | |
| B | LYS220 | |
| B | LYS267 | |
| B | PHE338 | |
| C | GLN161 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4 |
| Chain | Residue | Details |
| A | GLU165 | |
| B | GLU165 | |
| C | GLU165 | |
| D | GLU165 | |
| E | GLU165 | |
| F | GLU165 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23106432, ECO:0000269|PubMed:27966912, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF, ECO:0007744|PDB:5TJH |
| Chain | Residue | Details |
| A | ARG260 | |
| B | ARG260 | |
| C | ARG260 | |
| D | ARG260 | |
| E | ARG260 | |
| F | ARG260 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21502315, ECO:0000269|PubMed:21595445, ECO:0000269|PubMed:21984906, ECO:0000269|PubMed:22123821, ECO:0007744|PDB:2Q3E, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:3TDK |
| Chain | Residue | Details |
| A | ARG346 | |
| B | ARG346 | |
| C | ARG346 | |
| D | ARG346 | |
| E | ARG346 | |
| F | ARG346 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22123821, ECO:0000269|PubMed:23106432, ECO:0000305|PubMed:21502315, ECO:0000305|PubMed:21595445, ECO:0007744|PDB:2QG4, ECO:0007744|PDB:3KHU, ECO:0007744|PDB:3PRJ, ECO:0007744|PDB:3PTZ, ECO:0007744|PDB:4EDF |
| Chain | Residue | Details |
| A | ARG442 | |
| B | ARG442 | |
| C | ARG442 | |
| D | ARG442 | |
| E | ARG442 | |
| F | ARG442 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS107 | |
| B | LYS107 | |
| C | LYS107 | |
| D | LYS107 | |
| E | LYS107 | |
| F | LYS107 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| A | ASP280 | |
| A | ASN224 | |
| A | THR131 | |
| A | CYS276 | |
| A | LYS220 | |
| A | GLU165 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| B | ASP280 | |
| B | ASN224 | |
| B | THR131 | |
| B | CYS276 | |
| B | LYS220 | |
| B | GLU165 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| C | ASP280 | |
| C | ASN224 | |
| C | THR131 | |
| C | CYS276 | |
| C | LYS220 | |
| C | GLU165 |
| site_id | CSA4 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| D | ASP280 | |
| D | ASN224 | |
| D | THR131 | |
| D | CYS276 | |
| D | LYS220 | |
| D | GLU165 |
| site_id | CSA5 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| E | ASP280 | |
| E | ASN224 | |
| E | THR131 | |
| E | CYS276 | |
| E | LYS220 | |
| E | GLU165 |
| site_id | CSA6 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1dli |
| Chain | Residue | Details |
| F | ASP280 | |
| F | ASN224 | |
| F | THR131 | |
| F | CYS276 | |
| F | LYS220 | |
| F | GLU165 |
