3KHU
Crystal structure of human UDP-glucose dehydrogenase Glu161Gln, in complex with thiohemiacetal intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | UDP-glucose 6-dehydrogenase | polymer | 467 | 52082.4 | 6 | UniProt (O60701) Pfam (PF03721) Pfam (PF00984) Pfam (PF03720) | Homo sapiens (human) | UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH |
| 2 | AA, BA, G, H, IA... (E, A, F, B, C...) | URIDINE-5'-DIPHOSPHATE-GLUCOSE | non-polymer | 566.3 | 12 | Chemie (UPG) | |||
| 3 | CA, DA, EA, FA, GA... (E, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | Z (D) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | KA, LA, MA, NA, OA... (A, B, C, D, E...) | water | water | 18.0 | 1314 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 466 (UniProt: O60701)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gln 161 | Glu 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 312494.6 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 8089.1 | |
| All* | Total formula weight | 320583.7 |
