3K83

Crystal Structure Analysis of a Biphenyl/Oxazole/Carboxypyridine alpha-ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

3K83 の概要

• エントリーDOI: 10.2210/pdb3k83/pdb
• 関連するPDBエントリー: 2wj1 2wj2 3K84 3k7f
• 分子名称: Fatty-acid amide hydrolase 1, 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: faah, oxazole, conjugate, covalent modification, hydrolase, membrane, transmembrane, monotopic, fatty acid, serine hydrolase, endocannabinoid, reversible inhibitor.
• 由来する生物種: Rattus norvegicus (rat)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127241.94

構造登録者

Mileni, M.,Stevens, R.C.,Boger, D.L. (登録日: 2009-10-13, 公開日: 2009-12-01, 最終更新日: 2023-09-06)

• 主引用文献: Mileni, M.,Garfunkle, J.,Ezzili, C.,Kimball, F.S.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L.; X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.; J.Med.Chem., 53:230-240, 2010; PubMed: 19924997; DOI: 10.1021/jm9012196

実験手法

X-RAY DIFFRACTION (2.251 Å)