3K23
Glucocorticoid Receptor with Bound D-prolinamide 11
Summary for 3K23
Entry DOI | 10.2210/pdb3k23/pdb |
Related | 3K22 |
Descriptor | Glucocorticoid receptor, Nuclear receptor coactivator 2, 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, ... (4 entities in total) |
Functional Keywords | glucocorticoid receptor, steroid hormone receptor, nuclear receptor, gr, glucocorticoids, alpha helical sandwich, meta-channel, alternative initiation, chromatin regulator, disease mutation, dna-binding, metal-binding, nucleus, pseudohermaphroditism, receptor, steroid-binding, transcription, transcription regulation, zinc-finger, activator |
Biological source | Homo sapiens (human) |
Cellular location | Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150 Nucleus: Q15596 |
Total number of polymer chains | 6 |
Total formula weight | 96360.85 |
Authors | Biggadike, K.B.,McLay, I.M.,Madauss, K.P.,Williams, S.P.,Bledsoe, R.K. (deposition date: 2009-09-29, release date: 2009-10-27, Last modification date: 2024-04-03) |
Primary citation | Biggadike, K.,Bledsoe, R.K.,Coe, D.M.,Cooper, T.W.,House, D.,Iannone, M.A.,Macdonald, S.J.,Madauss, K.P.,McLay, I.M.,Shipley, T.J.,Taylor, S.J.,Tran, T.B.,Uings, I.J.,Weller, V.,Williams, S.P. Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor. Proc.Natl.Acad.Sci.USA, 106:18114-18119, 2009 Cited by PubMed: 19822747DOI: 10.1073/pnas.0909125106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report