3K23

Glucocorticoid Receptor with Bound D-prolinamide 11

3K23 の概要

• エントリーDOI: 10.2210/pdb3k23/pdb
• 関連するPDBエントリー: 3K22
• 分子名称: Glucocorticoid receptor, Nuclear receptor coactivator 2, 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, ... (4 entities in total)
• 機能のキーワード: glucocorticoid receptor, steroid hormone receptor, nuclear receptor, gr, glucocorticoids, alpha helical sandwich, meta-channel, alternative initiation, chromatin regulator, disease mutation, dna-binding, metal-binding, nucleus, pseudohermaphroditism, receptor, steroid-binding, transcription, transcription regulation, zinc-finger, activator
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Alpha: Cytoplasm . Isoform Beta: Nucleus . Isoform Alpha-B: Nucleus : P04150; Nucleus: Q15596
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 96360.85

構造登録者

Biggadike, K.B.,McLay, I.M.,Madauss, K.P.,Williams, S.P.,Bledsoe, R.K. (登録日: 2009-09-29, 公開日: 2009-10-27, 最終更新日: 2024-04-03)

• 主引用文献: Biggadike, K.,Bledsoe, R.K.,Coe, D.M.,Cooper, T.W.,House, D.,Iannone, M.A.,Macdonald, S.J.,Madauss, K.P.,McLay, I.M.,Shipley, T.J.,Taylor, S.J.,Tran, T.B.,Uings, I.J.,Weller, V.,Williams, S.P.; Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.; Proc.Natl.Acad.Sci.USA, 106:18114-18119, 2009; PubMed: 19822747; DOI: 10.1073/pnas.0909125106

実験手法

X-RAY DIFFRACTION (3 Å)