Structure of rat neuronal nitric oxide synthase D597N/M336V mutant heme domain in complex with N1-{(3'R,4'S)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine

Summary for 3JX4

Related3JWS 3JWT 3JWU 3JWV 3JWW 3JWX 3JWY 3JWZ 3JW0 3JW1 3JW2 3JW3 3JW5 3JW6
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsheme enzyme, substrate inhibitor, oxidoreductase
Biological sourceRattus norvegicus (rat)
Total number of polymer chains2
Total molecular weight100200.91
Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2009-09-18, release date: 2010-05-05, Last modification date: 2019-07-24)
Primary citation
Delker, S.L.,Ji, H.,Li, H.,Jamal, J.,Fang, J.,Xue, F.,Silverman, R.B.,Poulos, T.L.
Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.
J.Am.Chem.Soc., 132:5437-5442, 2010
PubMed: 20337441 (PDB entries with the same primary citation)
DOI: 10.1021/ja910228a
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2797 0.2% 4.3% 3.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21