3JWW

Structure of endothelial nitric oxide synthase heme domain complexed with N1-[(3'S,4'S)-4'-((6"-amino-4"-methylpyridin-2"-yl)methyl)pyrrolidin-3'-yl]-N2- (3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride

Summary for 3JWW

Entry DOI	10.2210/pdb3jww/pdb
Related	3JW0 3JW1 3JW2 3JW3 3JW4 3JW5 3JW6 3JWS 3JWT 3JWU 3JWV 3JWX 3JWY 3JWZ
Descriptor	Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
Functional Keywords	heme enzyme, substrate inhibitor, oxidoreductase
Biological source	Bos taurus (bovine)
Total number of polymer chains	2
Total formula weight	102463.30
Authors	Delker, S.L.,Li, H.,Poulos, T.L. (deposition date: 2009-09-18, release date: 2010-05-05, Last modification date: 2024-02-21)
Primary citation	Delker, S.L.,Ji, H.,Li, H.,Jamal, J.,Fang, J.,Xue, F.,Silverman, R.B.,Poulos, T.L. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. J.Am.Chem.Soc., 132:5437-5442, 2010 Cited by PubMed: 20337441 DOI: 10.1021/ja910228a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation