3IRO

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate

Summary for 3IRO

• Entry DOI: 10.2210/pdb3iro/pdb
• Related: 2H2Q 3CL9 3CLB 3HBB 3INV 3IRM 3IRN
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• Functional Keywords: trypanosoma cruzi, dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 4
• Total formula weight: 241162.04

Authors

Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2009-08-24, release date: 2010-07-28, Last modification date: 2023-09-06)

• Primary citation: Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y.; Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)