3IRO
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate
Summary for 3IRO
Entry DOI | 10.2210/pdb3iro/pdb |
Related | 2H2Q 3CL9 3CLB 3HBB 3INV 3IRM 3IRN |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total) |
Functional Keywords | trypanosoma cruzi, dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 4 |
Total formula weight | 241162.04 |
Authors | Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2009-08-24, release date: 2010-07-28, Last modification date: 2023-09-06) |
Primary citation | Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y. Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report