3IRO
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase complexed with NADPH and Q-8 antifolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 58928.1 | 4 | UniProt (Q27793) Pfam (PF00186) Pfam (PF00303) | Trypanosoma cruzi | DHFR-TS, Dihydrofolate reductase, Thymidylate synthase |
| 2 | E, K, P, W (A, B, C, D) | 5-[3-(3-fluorophenoxy)propoxy]quinazoline-2,4-diamine | non-polymer | 328.3 | 4 | Chemie (2CY) | |||
| 3 | F, L, Q, X (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 4 | G, M, R, S (A, B, C) | PHOSPHATE ION | non-polymer | 95.0 | 4 | Chemie (PO4) | |||
| 5 | AA, BA, H, I, J... (D, A, B, C) | ACETATE ION | non-polymer | 59.0 | 10 | Chemie (ACT) | |||
| 6 | N, T (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | CA, DA, EA, FA (A, B, C, D) | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235712.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5449.6 | |
| All* | Total formula weight | 241162.0 |
