3INV

Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE

Summary for 3INV

• Entry DOI: 10.2210/pdb3inv/pdb
• Related: 2H2Q 3CL9 3CLB 3HBB 3IRM 3IRN 3IRO
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 1-[3-(2,3-dichlorophenoxy)propoxy]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex, oxidoreductase/transferase
• Biological source: Trypanosoma cruzi
• Total number of polymer chains: 2
• Total formula weight: 121144.40

Authors

Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2009-08-13, release date: 2010-07-28, Last modification date: 2024-04-03)

• Primary citation: Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y.; Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.37 Å)