3HBB
Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate
Summary for 3HBB
Entry DOI | 10.2210/pdb3hbb/pdb |
Related | 2H2Q 3CL9 3CLB |
Descriptor | Dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (6 entities in total) |
Functional Keywords | bifunctional enzyme in complex with nadp and tmq, oxidoreductase, transferase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 4 |
Total formula weight | 243506.20 |
Authors | Schormann, N.,Senkovich, O.,Chattopadhyay, D. (deposition date: 2009-05-04, release date: 2009-05-19, Last modification date: 2023-09-06) |
Primary citation | Senkovich, O.,Schormann, N.,Chattopadhyay, D. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate. Acta Crystallogr.,Sect.D, 65:704-716, 2009 Cited by PubMed: 19564691DOI: 10.1107/S090744490901230X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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