3HBB
Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydrofolate reductase-thymidylate synthase | polymer | 521 | 58904.1 | 4 | UniProt (Q8T5T8) Pfam (PF00186) Pfam (PF00303) UniProt (by SIFTS) (Q27793) | Trypanosoma cruzi | |
| 2 | E, LA, O, X (A, D, B, C) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, MA, P, Y (A, D, B, C) | TRIMETREXATE | non-polymer | 370.4 | 4 | Chemie (TMQ) | |||
| 4 | AA, BA, CA, DA, EA... (C, A, D, B) | SULFATE ION | non-polymer | 96.1 | 28 | Chemie (SO4) | |||
| 5 | HA, IA, JA, KA, M... (C, A, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 6 | AB, BB, CB, DB (A, B, C, D) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235616.3 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 7889.9 | |
| All* | Total formula weight | 243506.2 |
