3INV
Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH NADPH, dUMP AND C-448 ANTIFOLATE
Summary for 3INV
Entry DOI | 10.2210/pdb3inv/pdb |
Related | 2H2Q 3CL9 3CLB 3HBB 3IRM 3IRN 3IRO |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 1-[3-(2,3-dichlorophenoxy)propoxy]-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | dhfr-ts antifolate complex, methyltransferase, multifunctional enzyme, nadp, nucleotide biosynthesis, one-carbon metabolism, oxidoreductase, transferase, oxidoreductase-transferase complex, oxidoreductase/transferase |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 2 |
Total formula weight | 121144.40 |
Authors | Chitnumsub, P.,Yuvaniyama, J.,Yuthavong, Y. (deposition date: 2009-08-13, release date: 2010-07-28, Last modification date: 2024-04-03) |
Primary citation | Chitnumsub, P.,Yuvaniyama, J.,Vilaivan, T.,Vanichtanankul, J.,Kamchonwongpaisan, S.,Yuthavong, Y. Structural basis of antifolate inhibition of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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