3HV7

Human p38 MAP Kinase in Complex with RL38

3HV7 の概要

• エントリーDOI: 10.2210/pdb3hv7/pdb
• 関連するPDBエントリー: 3GCP 3GCQ 3GCS 3GCU 3GCV 3HV3 3HV4 3HV5 3HV6
• 分子名称: Mitogen-activated protein kinase 14, 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea, octyl beta-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: dfg-out, type iii, rl38, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41960.91

構造登録者

Gruetter, C.,Simard, J.R.,Getlik, M.,Rauh, D. (登録日: 2009-06-15, 公開日: 2009-11-17, 最終更新日: 2023-09-06)

• 主引用文献: Kluter, S.,Grutter, C.,Naqvi, T.,Rabiller, M.,Simard, J.R.,Pawar, V.,Getlik, M.,Rauh, D.; Displacement assay for the detection of stabilizers of inactive kinase conformations.; J.Med.Chem., 53:357-367, 2010; PubMed: 19928858; DOI: 10.1021/jm901297e

実験手法

X-RAY DIFFRACTION (2.4 Å)