3HUB
Human p38 MAP Kinase in Complex with Scios-469
Summary for 3HUB
Entry DOI | 10.2210/pdb3hub/pdb |
Related | 3GCP 3GCQ 3GCS 3GCU 3GCV 3HUC |
Descriptor | Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide, ... (4 entities in total) |
Functional Keywords | dfg-in, glycine-rich loop, scios-469, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42040.35 |
Authors | Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2009-06-13, release date: 2010-03-09, Last modification date: 2024-02-21) |
Primary citation | Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations. J.Am.Chem.Soc., 132:4152-4160, 2010 Cited by PubMed: 20201574DOI: 10.1021/ja908083e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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