3HHU

Human heat-shock protein 90 (HSP90) in complex with {4-[3-(2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro-[1,2,4]triazol-4-yl]-benzyl}-carbamic acid ethyl ester {ZK 2819}

Summary for 3HHU

• Entry DOI: 10.2210/pdb3hhu/pdb
• Related: 1BYQ 1OSF 1UY6 1YC1 1YET 2BSM 2BTO 2BYI 2C2L 2CCT 2CCU
• Descriptor: Heat shock protein HSP 90-alpha, ethyl (4-{3-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-5-sulfanyl-4H-1,2,4-triazol-4-yl}benzyl)carbamate (3 entities in total)
• Functional Keywords: hsp90, atpase, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation, alternative splicing, cytoplasm, phosphoprotein, stress response
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P07900
• Total number of polymer chains: 2
• Total formula weight: 51249.80

Authors

Adler, M.,Whitlow, M. (deposition date: 2009-05-17, release date: 2009-07-14, Last modification date: 2024-02-21)

• Primary citation: Feldman, R.I.,Mintzer, B.,Zhu, D.,Wu, J.M.,Biroc, S.L.,Yuan, S.,Emayan, K.,Chang, Z.,Chen, D.,Arnaiz, D.O.,Bryant, J.,Ge, X.S.,Whitlow, M.,Adler, M.,Polokoff, M.A.,Li, W.W.,Ferrer, M.,Sato, T.,Gu, J.M.,Shen, J.,Tseng, J.L.,Dinter, H.,Buckman, B.; Potent triazolothione inhibitor of heat-shock protein-90.; Chem.Biol.Drug Des., 74:43-50, 2009; PubMed: 19519743; DOI: 10.1111/j.1747-0285.2009.00833.x

Experimental method

X-RAY DIFFRACTION (1.59 Å)