3HDZ
Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors
Summary for 3HDZ
Entry DOI | 10.2210/pdb3hdz/pdb |
Related | 1uho 2chm 2h40 2h42 2h44 3bjc 3HC8 |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A,cGMP-specific 3',5'-cyclic phosphodiesterase, 5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde5, pde-5, inhibition, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism allosteric enzyme, cgmp, cgmp-binding, magnesium, metal-binding, nucleotide-binding, zinc |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 37735.06 |
Authors | Cubbage, J.W.,Brown, D.G.,Jacobsen, E.J.,Walker, J.K.,Hughes, R.O. (deposition date: 2009-05-07, release date: 2009-07-07, Last modification date: 2024-05-22) |
Primary citation | Owen, D.R.,Walker, J.K.,Jon Jacobsen, E.,Freskos, J.N.,Hughes, R.O.,Brown, D.L.,Bell, A.S.,Brown, D.G.,Phillips, C.,Mischke, B.V.,Molyneaux, J.M.,Fobian, Y.M.,Heasley, S.E.,Moon, J.B.,Stallings, W.C.,Joseph Rogier, D.,Fox, D.N.,Palmer, M.J.,Ringer, T.,Rodriquez-Lens, M.,Cubbage, J.W.,Blevis-Bal, R.M.,Benson, A.G.,Acker, B.A.,Maddux, T.M.,Tollefson, M.B.,Bond, B.R.,Macinnes, A.,Yu, Y. Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Bioorg.Med.Chem.Lett., 19:4088-4091, 2009 Cited by PubMed: 19540112DOI: 10.1016/j.bmcl.2009.06.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report