3HDZ

Identification, Synthesis, and SAR of Amino Substituted Pyrido[3,2b]pryaziones as Potent and Selective PDE5 Inhibitors

3HDZ の概要

• エントリーDOI: 10.2210/pdb3hdz/pdb
• 関連するPDBエントリー: 1uho 2chm 2h40 2h42 2h44 3HC8 3bjc
• 分子名称: cGMP-specific 3',5'-cyclic phosphodiesterase,cAMP-specific 3',5'-cyclic phosphodiesterase 4A,cGMP-specific 3',5'-cyclic phosphodiesterase, 5-amino-1-butyl-7-phenyl-1,6-naphthyridin-4(1H)-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: pde5, pde-5, inhibition, alternative splicing, camp, hydrolase, phosphoprotein, polymorphism allosteric enzyme, cgmp, cgmp-binding, magnesium, metal-binding, nucleotide-binding, zinc
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37735.06

構造登録者

Cubbage, J.W.,Brown, D.G.,Jacobsen, E.J.,Walker, J.K.,Hughes, R.O. (登録日: 2009-05-07, 公開日: 2009-07-07, 最終更新日: 2023-07-26)

• 主引用文献: Owen, D.R.,Walker, J.K.,Jon Jacobsen, E.,Freskos, J.N.,Hughes, R.O.,Brown, D.L.,Bell, A.S.,Brown, D.G.,Phillips, C.,Mischke, B.V.,Molyneaux, J.M.,Fobian, Y.M.,Heasley, S.E.,Moon, J.B.,Stallings, W.C.,Joseph Rogier, D.,Fox, D.N.,Palmer, M.J.,Ringer, T.,Rodriquez-Lens, M.,Cubbage, J.W.,Blevis-Bal, R.M.,Benson, A.G.,Acker, B.A.,Maddux, T.M.,Tollefson, M.B.,Bond, B.R.,Macinnes, A.,Yu, Y.; Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.; Bioorg.Med.Chem.Lett., 19:4088-4091, 2009; PubMed: 19540112; DOI: 10.1016/j.bmcl.2009.06.012

実験手法

X-RAY DIFFRACTION (1.8 Å)