3HCE

Crystal Structure of E185D hPNMT in Complex With Octopamine and AdoHcy

3HCE の概要

• エントリーDOI: 10.2210/pdb3hce/pdb
• 関連するPDBエントリー: 1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 2AN5 2G70 2G71 2G72 2G8N 2OBF 2ONY 2ONZ 2OPB 3HCA 3HCB 3HCC 3HCD 3HCF
• 分子名称: Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 4-(2R-AMINO-1-HYDROXYETHYL)PHENOL, ... (4 entities in total)
• 機能のキーワード: methyltransferase, catecholamine biosynthesis, polymorphism, s-adenosyl-l-methionine, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64739.06

構造登録者

Drinkwater, N.,Martin, J.L. (登録日: 2009-05-06, 公開日: 2009-08-25, 最終更新日: 2023-09-06)

• 主引用文献: Drinkwater, N.,Gee, C.L.,Puri, M.,Criscione, K.R.,McLeish, M.J.,Grunewald, G.L.,Martin, J.L.; Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.; Biochem.J., 422:463-471, 2009; PubMed: 19570037; DOI: 10.1042/BJ20090702

実験手法

X-RAY DIFFRACTION (2.85 Å)