2AN3

Structure of PNMT with S-adenosyl-L-homocysteine and the semi-rigid analogue acceptor substrate cis-(1R,2S)-2-amino-1-tetralol.

Summary for 2AN3

Entry DOI	10.2210/pdb2an3/pdb
Related	1HNN 1N7I 1N7J 1YZ3 2AN4 2AN5
Descriptor	Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, ... (4 entities in total)
Functional Keywords	methyltransferase, substrate structure, s-adenosyl-l-methionine, adrenaline synthesis, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64787.19
Authors	Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. (deposition date: 2005-08-11, release date: 2006-03-14, Last modification date: 2023-10-25)
Primary citation	Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis Biochemistry, 44:16875-16885, 2005 Cited by PubMed: 16363801 DOI: 10.1021/bi051636b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation