2G8N

Structure of hPNMT with inhibitor 3-Hydroxymethyl-7-(N-4-chlorophenylaminosulfonyl)-THIQ and AdoHcy

Summary for 2G8N

Entry DOI	10.2210/pdb2g8n/pdb
Related	1HNN 1N7J 1NJI 1YZ3 2AN3 2AN4
Descriptor	Phenylethanolamine N-methyltransferase, (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywords	methyltransferase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	65166.43
Authors	Drinkwater, N.,Gee, C.L.,Martin, J.L. (deposition date: 2006-03-02, release date: 2006-09-12, Last modification date: 2023-10-25)
Primary citation	Grunewald, G.L.,Seim, M.R.,Regier, R.C.,Martin, J.L.,Gee, C.L.,Drinkwater, N.,Criscione, K.R. Comparison of the Binding of 3-Fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with Their Isosteric Sulfonamides to the Active Site of Phenylethanolamine N-Methyltransferase J.Med.Chem., 49:5424-5433, 2006 Cited by PubMed: 16942016 DOI: 10.1021/jm060466d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation