3H7W
Crystal structure of the high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains with the artificial ligand THS017
Summary for 3H7W
Entry DOI | 10.2210/pdb3h7w/pdb |
Related | 1P97 1X0O 2A24 2B02 3f1n 3f1o 3f1p 3H82 |
Descriptor | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 2-nitro-N-(thiophen-3-ylmethyl)-4-(trifluoromethyl)aniline, ... (4 entities in total) |
Functional Keywords | pas domain, heterodimer, protein ligand complex., activator, angiogenesis, congenital erythrocytosis, developmental protein, differentiation, disease mutation, dna-binding, hydroxylation, nucleus, phosphoprotein, transcription, transcription regulation, ubl conjugation, alternative splicing, polymorphism |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): Q99814 Nucleus: P27540 |
Total number of polymer chains | 2 |
Total formula weight | 28083.67 |
Authors | Key, J.M.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. (deposition date: 2009-04-28, release date: 2010-01-12, Last modification date: 2023-09-06) |
Primary citation | Key, J.,Scheuermann, T.H.,Anderson, P.C.,Daggett, V.,Gardner, K.H. Principles of ligand binding within a completely buried cavity in HIF2alpha PAS-B J.Am.Chem.Soc., 131:17647-17654, 2009 Cited by PubMed: 19950993DOI: 10.1021/ja9073062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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