3GYF
Human DHFR with Z-isomer in Orthorhombic lattice
Summary for 3GYF
Entry DOI | 10.2210/pdb3gyf/pdb |
Related | 1u72 3d7x |
Descriptor | Dihydrofolate reductase, 5-[(1Z)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | human dihydrofolate reductase packing, z-isomer furopyrimidine, nadp, one-carbon metabolism, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 22810.66 |
Authors | Cody, V. (deposition date: 2009-04-03, release date: 2009-11-03, Last modification date: 2023-09-06) |
Primary citation | Cody, V.,Pace, J.,Lin, L.,Gangjee, A. The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex. Acta Crystallogr.,Sect.F, 65:762-766, 2009 Cited by PubMed: 19652333DOI: 10.1107/S1744309109025548 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
Download full validation report