3GYF

Human DHFR with Z-isomer in Orthorhombic lattice

Summary for 3GYF

Entry DOI	10.2210/pdb3gyf/pdb
Related	1u72 3d7x
Descriptor	Dihydrofolate reductase, 5-[(1Z)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	human dihydrofolate reductase packing, z-isomer furopyrimidine, nadp, one-carbon metabolism, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	22810.66
Authors	Cody, V. (deposition date: 2009-04-03, release date: 2009-11-03, Last modification date: 2023-09-06)
Primary citation	Cody, V.,Pace, J.,Lin, L.,Gangjee, A. The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex. Acta Crystallogr.,Sect.F, 65:762-766, 2009 Cited by PubMed: 19652333 DOI: 10.1107/S1744309109025548 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation