4Q4R
tRNA-Guanine Transglycosylase (TGT) in Complex with 2-{[2-(Morpholin-4-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one
Replaces: 3V0YReplaces: 3GFNSummary for 4Q4R
Entry DOI | 10.2210/pdb4q4r/pdb |
Related | 1P0D 4Q4M 4Q4O 4Q4P 4Q4Q 4Q4S |
Descriptor | Queuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (5 entities in total) |
Functional Keywords | transferase, guanine exchange enzyme, preq1, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Zymomonas mobilis subsp. mobilis |
Total number of polymer chains | 1 |
Total formula weight | 43581.74 |
Authors | |
Primary citation | Neeb, M.,Betz, M.,Heine, A.,Barandun, L.J.,Hohn, C.,Diederich, F.,Klebe, G. Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of a Flat Structure-Activity Relationship for Inhibition of a tRNA-Modifying Enzyme. J.Med.Chem., 57:5566-5578, 2014 Cited by PubMed: 24960372DOI: 10.1021/jm5006868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.448 Å) |
Structure validation
Download full validation report