4Q4O

tRNA-Guanine Transglycosylase (TGT) in Complex with 6-Amino-2-{[2-(piperidin-1-yl)ethyl]amino}-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one

Summary for 4Q4O

• Entry DOI: 10.2210/pdb4q4o/pdb
• Related: 4Q4M 4Q4P 4Q4Q 4Q4R 4Q4S
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, DIMETHYL SULFOXIDE, ... (7 entities in total)
• Functional Keywords: transferase, guanine exchange enzyme, preq1, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis
• Total number of polymer chains: 1
• Total formula weight: 43616.27

Authors

Neeb, M.,Heine, A.,Klebe, G. (deposition date: 2014-04-15, release date: 2014-07-09, Last modification date: 2023-09-20)

• Primary citation: Neeb, M.,Betz, M.,Heine, A.,Barandun, L.J.,Hohn, C.,Diederich, F.,Klebe, G.; Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of a Flat Structure-Activity Relationship for Inhibition of a tRNA-Modifying Enzyme.; J.Med.Chem., 57:5566-5578, 2014; PubMed: 24960372; DOI: 10.1021/jm5006868

Experimental method

X-RAY DIFFRACTION (1.35 Å)