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4Q4S

tRNA-Guanine Transglycosylase (TGT) in Complex with 6-Amino-2-[(thiophen-2-ylmethyl)amino]-1H,7H,8H-imidazo[4,5-g]quinazolin-8-one

Replaces:  3C2Z
Summary for 4Q4S
Entry DOI10.2210/pdb4q4s/pdb
Related1P0D 4Q4M 4Q4O 4Q4P 4Q4Q 4Q4R
DescriptorQueuine tRNA-ribosyltransferase, ZINC ION, GLYCEROL, ... (5 entities in total)
Functional Keywordstransferase, guanine exchange enzyme, preq1, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceZymomonas mobilis subsp. mobilis
Total number of polymer chains1
Total formula weight43671.84
Authors
Neeb, M.,Heine, A.,Klebe, G. (deposition date: 2014-04-15, release date: 2014-07-09, Last modification date: 2023-09-20)
Primary citationNeeb, M.,Betz, M.,Heine, A.,Barandun, L.J.,Hohn, C.,Diederich, F.,Klebe, G.
Beyond Affinity: Enthalpy-Entropy Factorization Unravels Complexity of a Flat Structure-Activity Relationship for Inhibition of a tRNA-Modifying Enzyme.
J.Med.Chem., 57:5566-5578, 2014
Cited by
PubMed: 24960372
DOI: 10.1021/jm5006868
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.249 Å)
Structure validation

217705

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