3F9K
Two domain fragment of HIV-2 integrase in complex with LEDGF IBD
3F9K の概要
エントリーDOI | 10.2210/pdb3f9k/pdb |
関連するPDBエントリー | 1K6Y 2B4J |
分子名称 | Integrase, PC4 and SFRS1-interacting protein, ZINC ION, ... (4 entities in total) |
機能のキーワード | protein-protein complex, aids, dna integration, endonuclease, magnesium, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, nucleus, transferase, viral nucleoprotein, virion, dna-binding, host-virus interaction, transcription, transcription regulation, zinc binding, hhcc motif, viral protein, recombination |
由来する生物種 | Human immunodeficiency virus type 2 (HIV-2) 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04584 Nucleus: O75475 |
タンパク質・核酸の鎖数 | 36 |
化学式量合計 | 703193.57 |
構造登録者 | |
主引用文献 | Hare, S.,Shun, M.C.,Gupta, S.S.,Valkov, E.,Engelman, A.,Cherepanov, P. A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75 Plos Pathog., 5:e1000259-e1000259, 2009 Cited by PubMed: 19132083DOI: 10.1371/journal.ppat.1000259 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
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