3F7H

Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic

3F7H の概要

• エントリーDOI: 10.2210/pdb3f7h/pdb
• 関連するPDBエントリー: 1tw6 2i3h 2i3i 3F7G 3F7I
• 分子名称: Baculoviral IAP repeat-containing protein 7, ZINC ION, N-[(3aR,6S,6aS)-1-(N-methyl-L-alanyl-3-methyl-L-valyl)octahydrocyclopenta[b]pyrrol-6-yl]-2,2-diphenylacetamide, ... (7 entities in total)
• 機能のキーワード: zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, apoptosis, metal-binding, nucleus, zinc-finger
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31463.65

構造登録者

Franklin, M.C.,Fairbrother, W.J.,Cohen, F. (登録日: 2008-11-09, 公開日: 2009-03-17, 最終更新日: 2024-04-03)

• 主引用文献: Cohen, F.,Alicke, B.,Elliott, L.O.,Flygare, J.A.,Goncharov, T.,Keteltas, S.F.,Franklin, M.C.,Frankovitz, S.,Stephan, J.P.,Tsui, V.,Vucic, D.,Wong, H.,Fairbrother, W.J.; Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold; J.Med.Chem., 52:1723-1730, 2009; PubMed: 19228017; DOI: 10.1021/jm801450c

実験手法

X-RAY DIFFRACTION (1.8 Å)